The RELIEF Study is looking for patients with migraine headaches who will be evaluated to determine if they have a PFO. If they do, the patients will move on to additional screening to ensure selection of patients who may potentially benefit from PFO closure .
Study participants must also meet the following criteria:
- Be 18 - 55 years of age.
- Have had one year or more of migraine symptoms that started before the age of 50.
- Have more than one migraine headache per week on average.
- Have tried and have had unsatisfactory results with at least two different migraine medications for prevention, which were taken on a regular basis to reduce the overall frequency and/or severity of migraine.
Additional criteria will apply.